In theory, in order for Specific PD Tolerance to occur, what must happen?

In theory, in order for Specific PD Tolerance to occur, what must happen?

a) The drug must disrupt functioning of the organism in order for the “homeostatic mechanism” to kick in

b) A person must be experiencing disruption in homeostatic before taking the drug

c) A person must self-administer the drug in frequent intervals with increasing doses

d) B and C

 

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