Which of the following is NOT true of Pharmacodynamic tolerance:

Which of the following is NOT true of Pharmacodynamic tolerance:

a) It is compensatory in nature, which is relatable to a homeostatic mechanism trying to regain balance

b) All effects of the drug are diminished to the same extent because there is reduced bioavailability of drug at target site

c) If upregulation or downregulation of receptor population occurs, all effects of drug will be diminished

d) Tolerance to a specific effect of the drug may develop independently from other effects of the drug (e.g. hypothermic effect of alcohol)

 

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